The aim of the project is to elucidate the connection between genetics and molecular traits in people living with HIV. The 2000HIV cohort is a large, multi-omics cohort of people living with HIV. The cohort consists of 2000 individuals from Europe, Africa and Asia. The cohort is described in detail in Vos et al. [1] . For this project, we focused on the European individuals (n ~ 1300).
We performed Quantitative Trait Loci (QTL) mapping for three baseline omics (gene expression, proteins and metabolites), and (most importantly) cytokine production. The European cohort was split into a discovery cohort (n ~ 1000) and a validation cohort (n ~ 250). QTL mapping was done using our snakemake pipeline QTLmake [2] .
Botey-Bataller J, van Unen N, et al., Nature Medicine 2025 . https://doi.org/10.1038/s41591-025-03887-1
Nienke van Unen - nienke.vanunen(at)helmholtz-hzi.de
Javier Botey-Bataller - javier.botey(at)helmholtz-hzi.de
Prof. Dr. Yang Li - yang.li(at)helmholtz-hzi.de
Mendelian Randomisation
Causal effect of baseline gene expression and circulating molecules on cytokine expression upon different stimuli. The results shown here are from the Inverse variance weighted (IVW) method.